[Answer] 1. Since insulin plays such a pivotal role in reducing blood glucose, it is unsurprising that problems arise when tissues such as the liver develop insulin resistance. What does the term "insulin resistance" refer to?

Step 1 : Introduction to the question "1. Since insulin plays such a pivotal role in reducing blood glucose, it is unsurprising that problems arise when tissues such as the liver develop insulin resistance. What does the term "insulin resistance" refer to?"

...1. The inability to sense and respond to insulin signalling 2. A mutation to the gene coding for insulin 3. A reduction in insulin secretion 4. Death of pancreatic cells Insulin resistance has essentially the same effect as having little/no insulin, meaning that glycolysis, glycogen synthesis and glucose uptake are impaired and so blood glucose remains high.

Step 2 : Answer to the question "1. Since insulin plays such a pivotal role in reducing blood glucose, it is unsurprising that problems arise when tissues such as the liver develop insulin resistance. What does the term "insulin resistance" refer to?"

The inability to sense and respond to insulin signalling:

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