[Answer] The 1928 discovery of what revolutionized modern medicine?

Step 1 : Introduction to the question "The 1928 discovery of what revolutionized modern medicine?"

...On an autumn day in 1928 London, Dr. Alexander Fleming made one of the most important discoveries in medical history: Penicillin. He happened on it by chance when he returned to a messy lab after a vacation and noticed that the mold Penicillium inhibited bacterial growth on his samples. The bacteriologist revolutionized modern medicine by discovering the world’s first antibiotic.

[Answer] Which cartoon character debuted in the 1928 short “Steamboat Willie”?

Step 1 : Introduction to the question "Which cartoon character debuted in the 1928 short “Steamboat Willie”?"

...The first official debut of this famous mouse was in 1928 in “Steamboat Willie” at New York’s Colony Theatre. It was one of the very first cartoons to successfully use synchronized sound, making it an instant hit. After its success, a cartoon star was born and Walt Disney set out to create more characters that we still watch today.

[Answer] In 1927, which aviator crossed the Atlantic in the Spirit of St. Louis?

Step 1 : Introduction to the question "In 1927, which aviator crossed the Atlantic in the Spirit of St. Louis?"

...On May 12, 1927, Charles Lindbergh flew the Spirit of St. Louis from San Diego to New York City, setting the record for the fastest transcontinental flight at the time. A few days later, on May 20, he departed New York’s Roosevelt Field and set course for Europe. After 33.5 hours in the air, Lindbergh landed at Le Bourget Aerodrome in Paris, completing the 3,600-mile trip. This marked the first solo, nonstop transatlantic flight and the first nonstop flight from New York to Paris.

[Answer] Which novel was set in the Roaring ’20s?

Step 1 : Introduction to the question "Which novel was set in the Roaring ’20s?"

...We have the 1920s to thank for some of the most memorable novels in history, such as Ernest Hemingway’s “The Sun Also Rises,” and James Joyce's “Ulysses,” but perhaps no writer exemplifies the Jazz Age more than F. Scott Fitzgerald. He was inspired by glamorous parties he attended on Long Island’s North Shore to write “The Great Gatsby.” The 1925 novel depicts narrator Nick Carraway’s fascination with the millionaire Jay Gatsby and his obsession with former girlfriend Daisy Buchanan.

[Answer] Route 66 opened in 1926 running between what two cities?

Step 1 : Introduction to the question "Route 66 opened in 1926 running between what two cities?"

...The 1920s kicked off the rise of the automobile, and with it, many new routes criss-crossing the country. Route 66 was commissioned in 1926 and became fully paved within a decade. Running from Chicago to Los Angeles, the “Mother Road,” as it was sometimes called, helped connect dozens of small towns and opened up a new trucking route, boosting business along the way.

[Answer] What is widely considered to be the first modern airplane?

Step 1 : Introduction to the question "What is widely considered to be the first modern airplane?"

...Aviation pioneers Orville and Wilbur Wright invented and flew the first modern airplane, known as the Wright Flyer, in 1903. On December 17, Orville took to the skies over Kitty Hawk, North Carolina, traveling 120 feet in 12 seconds — the first successful flight of a powered heavier-than-air aircraft. The world was never the same again.

[Answer] What millionaire aviator designed and flew the famous Spruce Goose?

Step 1 : Introduction to the question "What millionaire aviator designed and flew the famous Spruce Goose?"

...In 1942, amid World War II, the U.S. needed to transport millions of tons of material across the Atlantic Ocean. But metals were hard to come by, so the government began looking for other options. The task eventually fell to eccentric business magnate and aviator Howard Hughes to design a wooden plane six times larger than any other at the time. The Spruce Goose made its first and only flight on November 2, 1947, with Hughes in the pilot's seat.